|
|
tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH + H+
|
1.5.1.3
dihydrofolate reductase
1.5.1.33
pteridine reductase
1.5.1.34
6,7-dihydropteridine reductase
1.5.1.50
dihydromonapterin reductase
|
–
–
–
–
|
BMK
|
|
BRENDA:
BR36900
KEGG:
R00939
MetaCyc:
DIHYDROFOLATEREDUCT-RXN;
RXN-19329
|
|
|
|
tetrahydrofolate + ATP + formate <=> 10-formyltetrahydrofolate + ADP + phosphate
|
6.3.4.3
formate---tetrahydrofolate ligase
|
–
|
BMK
|
|
BRENDA:
BR140;
BS443140
KEGG:
R00943
MetaCyc:
FORMATETHFLIG-RXN
SABIO-RK:
51
|
|
|
|
5-formimidoyltetrahydrofolate + L-glutamate <=> N-formimino-L-glutamate + tetrahydrofolate
|
2.1.2.5
glutamate formimidoyltransferase
|
–
|
BMK
|
|
BRENDA:
BR43944;
BS451911
KEGG:
R02287
MetaCyc:
GLUTAMATE-FORMIMINOTRANSFERASE-RXN
SABIO-RK:
2252
|
|
|
|
tetrahydrofolate + L-glutamate + ATP <=> tetrahydrofolate + ADP + phosphate
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
BMK
|
|
BRENDA:
BR109
KEGG:
R04241
MetaCyc:
FOLYLPOLYGLUTAMATESYNTH-RXN
|
|
|
|
10-formyltetrahydrofolate + H2O <=> tetrahydrofolate + formate + H+
|
3.5.1.10
formyltetrahydrofolate deformylase
|
–
|
BMK
|
|
BRENDA:
BR22680
KEGG:
R00944
MetaCyc:
FORMYLTHFDEFORMYL-RXN
SABIO-RK:
1259
|
|
|
|
10-formyltetrahydrofolate + H2O + NADP+ <=> tetrahydrofolate + CO2 + NADPH + H+
|
1.5.1.6
formyltetrahydrofolate dehydrogenase
|
–
|
K
|
|
BRENDA:
BR36903
KEGG:
R00941
MetaCyc:
FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN
SABIO-RK:
1257
|
|
|
|
N,N-dimethylglycine + tetrahydrofolate + flavin <=> sarcosine + 5,10-methylenetetrahydrofolate + reduced_flavodoxin
|
1.5.8.4
dimethylglycine dehydrogenase
|
–
|
K
|
|
BRENDA:
BR36914
KEGG:
R01565
|
|
|
|
L-homocysteine + 5-methyltetrahydrofolate <=> L-methionine + tetrahydrofolate
|
2.1.1.13
methionine synthase
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
|
–
–
|
BMK
|
|
BRENDA:
BR40552
KEGG:
R00946
MetaCyc:
HOMOCYSMETB12-RXN
SABIO-RK:
1260
|
|
|
|
L-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O
|
2.1.2.1
glycine hydroxymethyltransferase
|
–
|
BMK
|
|
BRENDA:
BR40573
KEGG:
R00945
MetaCyc:
GLYOHMETRANS-RXN
SABIO-RK:
95
|
|
|
|
tetrahydrofolate + Trimethylsulfonium <=> H+ + Dimethylsulfide + 5-methyltetrahydrofolate
|
2.1.1.19
trimethylsulfonium---tetrahydrofolate N-methyltransferase
|
–
|
K
|
|
BRENDA:
BR43885
KEGG:
R02573
MetaCyc:
2.1.1.19-RXN
|
|
|
|
5,10-methylenetetrahydrofolate + 2-oxoisovalerate + H2O <=> ketopantoate + tetrahydrofolate
|
2.1.2.11
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
–
|
BMK
|
|
BRENDA:
BR43940
KEGG:
R01226
MetaCyc:
3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN
SABIO-RK:
1455
|
|
|
|
10-formyltetrahydrofolate + beta-glycinamide_ribonucleotide <=> tetrahydrofolate + formylglycinamide_ribonucleotide + H+
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
BMK
|
|
BRENDA:
BR43941
KEGG:
R04325
MetaCyc:
GART-RXN
|
|
|
|
10-formyltetrahydrofolate + 5-aminoimidazole-4-carboxamide_ribonucleotide <=> tetrahydrofolate + 5-Formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
BMK
|
|
BRENDA:
BR43942
KEGG:
R04560
MetaCyc:
AICARTRANSFORM-RXN
SABIO-RK:
122
|
|
|
|
5-formimidoyltetrahydrofolate + glycine <=> Formiminoglycine + tetrahydrofolate
|
2.1.2.4
glycine formimidoyltransferase
|
–
|
BMK
|
|
BRENDA:
BR43943
KEGG:
R02729
MetaCyc:
GLYCINE-FORMIMINOTRANSFERASE-RXN
|
|
|
|
5,10-methylenetetrahydrofolate + D-alanine + H2O <=> 2-methyl-DL-serine + tetrahydrofolate
|
2.1.2.1
glycine hydroxymethyltransferase
2.1.2.7
D-alanine 2-hydroxymethyltransferase
|
–
–
|
K
|
|
BRENDA:
BR43945
KEGG:
R01225
MetaCyc:
D-ALANINE-HYDROXYMETHYLTRANSFERASE-RXN
|
|
|
|
dCMP + H2O + 5,10-methylenetetrahydrofolate <=> 2''-deoxy-5-hydroxymethylcytidine_5''-phosphate + tetrahydrofolate
|
2.1.2.8
deoxycytidylate 5-hydroxymethyltransferase
2.1.2.B2
|
–
–
|
K
|
|
BRENDA:
BR43946
KEGG:
R01669
MetaCyc:
2.1.2.8-RXN
|
|
|
|
dUMP + 5,10-methylenetetrahydrofolate + NADPH + H+ <=> dTMP + tetrahydrofolate + NADP+
|
1.5.1.3
dihydrofolate reductase
2.1.1.148
thymidylate synthase (FAD)
|
–
–
|
MK
|
|
BRENDA:
BR47450
KEGG:
R06613
MetaCyc:
RXN-8850
SABIO-RK:
7840
|
|
|
|
3-(methylthio)propanoate + 5-methyltetrahydrofolate + H+ <=> dimethylsulfoniopropionate + tetrahydrofolate
|
2.1.1.269
dimethylsulfoniopropionate demethylase
|
–
|
MK
|
|
BRENDA:
BR49172
KEGG:
R10333
MetaCyc:
RXN-9736
|
|
|
|
UDP-4-amino-4-deoxy-beta-L-arabinopyranose + 10-formyltetrahydrofolate <=> UDP-4-deoxy-4-formamido-beta-L-arabinopyranose + tetrahydrofolate + H+
|
2.1.2.13
UDP-4-amino-4-deoxy-L-arabinose formyltransferase
|
–
|
MK
|
|
BRENDA:
BR49173
KEGG:
R07660
MetaCyc:
RXN0-1862
|
|
|
|
vanillic_acid + tetrahydrofolate <=> 3,4-dihydroxybenzoate + 5-methyltetrahydrofolate
|
2.1.1.341
vanillate/3-O-methylgallate O-demethylase
|
–
|
MK
|
|
BRENDA:
BR52053
KEGG:
R10136
MetaCyc:
RXN-2
|
|
|
|
5-methoxygallic_acid + tetrahydrofolate <=> gallic_acid + 5-methyltetrahydrofolate
|
2.1.1.341
vanillate/3-O-methylgallate O-demethylase
|
–
|
MK
|
|
BRENDA:
BR52054
KEGG:
R09271
MetaCyc:
RXN-10892
|
|
|
|
sesamin + tetrahydrofolate <=> (+)-demethylpiperitol + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BR52315
KEGG:
R11955
MetaCyc:
RXN-18465
|
|
|
|
(+)-demethylpiperitol + tetrahydrofolate <=> (+)-didemethylpinoresinol + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BR52316
KEGG:
R11956
MetaCyc:
RXN-18466
|
|
|
|
folate + NADPH <=> tetrahydrofolate + NADP+
|
1.5.1.3
dihydrofolate reductase
1.5.1.33
pteridine reductase
1.5.1.34
6,7-dihydropteridine reductase
|
–
–
–
|
K
|
|
BRENDA:
BS259283
KEGG:
R00940
SABIO-RK:
1256
|
|
|
|
folate + NADH <=> tetrahydrofolate + NAD+
|
1.5.1.3
dihydrofolate reductase
1.5.1.34
6,7-dihydropteridine reductase
|
–
–
|
K
|
|
BRENDA:
BS319536-a
KEGG:
R00937
|
|
|
|
5,10-methylenetetrahydrofolate + tRNA_UpsiC + FADH2 <=> tetrahydrofolate + tRNA_TpsiC + FAD
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
BRENDA:
BS319868
KEGG:
R03704
|
|
|
|
S-aminomethyldihydrolipoylprotein + tetrahydrofolate <=> dihydrolipoylprotein + 5,10-methylenetetrahydrofolate + NH3
|
2.1.2.10
aminomethyltransferase
|
–
|
K
|
|
BRENDA:
BS320028
KEGG:
R04125
|
|
|
|
formaldehyde + tetrahydrofolate <=> 5,10-methylenetetrahydrofolate + H2O
|
2.1.2.11
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
–
|
M
|
|
BRENDA:
BS320035
KEGG:
R09093
MetaCyc:
RXN-2881
|
|
|
|
5-formyltetrahydrofolate + L-glutamate <=> N-formyl-L-glutamate + tetrahydrofolate + H+
|
2.1.2.5
glutamate formimidoyltransferase
|
–
|
K
|
|
BRENDA:
BS320077
KEGG:
R03189
MetaCyc:
RXN-20716
|
|
|
|
ATP + tetrahydrofolate + L-glutamate <=> ADP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
K
|
|
BRENDA:
BS369045;
BS369050
KEGG:
R00942
|
|
|
|
5,10-methylenetetrahydrofolate + tRNA_UpsiC + NADH <=> tetrahydrofolate + tRNA_TpsiC + NAD+
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
BRENDA:
BS420099
KEGG:
R12548
|
|
|
|
7,8-dihydrofolate + NADH + H+ <=> tetrahydrofolate + NAD+
|
1.5.1.3
dihydrofolate reductase
|
–
|
K
|
|
BRENDA:
BS424618
KEGG:
R00936
SABIO-RK:
1254
|
|
|
|
syringic_acid + tetrahydrofolate <=> 5-methoxygallic_acid + 5-methyltetrahydrofolate
|
2.1.1
2.1.1.341
vanillate/3-O-methylgallate O-demethylase
|
–
–
|
MK
|
|
BRENDA:
BS438468
KEGG:
R09270
MetaCyc:
RXN-10890
|
|
|
|
glycine + tetrahydrofolate + NAD+ <=> 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
|
1.4.1.f
1.4.4.2
glycine dehydrogenase (aminomethyl-transferring)
1.8.1.4
dihydrolipoyl dehydrogenase
2.1.2.10
aminomethyltransferase
|
–
–
–
–
|
MK
|
|
KEGG:
R01221
MetaCyc:
GCVMULTI-RXN
SABIO-RK:
1451
|
|
|
|
tetrahydrofolate + H2O <=> tetrahydrofolate + L-glutamate
|
3.4.19.9
folate gamma-glutamyl hydrolase
|
–
|
MK
|
|
KEGG:
R04242
MetaCyc:
RXN-3741
|
|
|
|
D-serine + tetrahydrofolate <=> glycine + 5,10-methylenetetrahydrofolate + H2O
|
2.1.2.1
glycine hydroxymethyltransferase
|
–
|
|
|
BRENDA:
BS409177
SABIO-RK:
15181
|
|
|
|
5-methyltetrahydrofolate + corrinoid + H+ <=> methylcorrinoid_protein + tetrahydrofolate
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
K
|
|
KEGG:
R02289
|
|
|
|
serotonin + 5-methyltetrahydrofolate <=> 5-methoxytryptamine + tetrahydrofolate
|
2.1.1
|
–
|
K
|
|
KEGG:
R02912
|
|
|
|
Met-tRNA + 10-formyltetrahydrofolate <=> tetrahydrofolate + N-formylmethionyl-tRNA
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
K
|
|
KEGG:
R03940
|
|
|
|
5''-Phosphoribosylglycinamide + 5,10-methenyltetrahydrofolate + H2O <=> 5''-Phosphoribosyl-N-formylglycinamide + tetrahydrofolate
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
K
|
|
KEGG:
R04326
|
|
|
|
tRNA_containing_2-thiouridine + glycine + 5-formyltetrahydrofolate + reduced_acceptor <=> tRNA_containing_5-carboxymethylaminomethyl-2-thiouridine + tetrahydrofolate + acceptor + H2O
|
not assigned
|
–
|
|
|
KEGG:
R08701
|
|
|
|
tetrahydrofolate + acetyl-CoA <=> 5-methyltetrahydrofolate + CoA + CO
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
2.3.1.169
CO-methylating acetyl-CoA synthase
|
–
–
|
K
|
|
KEGG:
R10243
|
|
|
|
5,10-methylenetetrahydrofolate + uracil54_in_tRNA + NADPH + H+ <=> tetrahydrofolate + 5-methyluracil54_in_tRNA + NADP+
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
MetaCyc:
2.1.1.74-RXN
|
|
|
|
5,10-methylenetetrahydrofolate + uracil54_in_tRNA + NADH + H+ <=> tetrahydrofolate + 5-methyluracil54_in_tRNA + NAD+
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
MetaCyc:
2.1.1.74-RXN_WOP
|
|
|
|
N,N-dimethylglycine + tetrahydrofolate + oxidized_electron_transfer_flavoprotein + H+ <=> sarcosine + 5,10-methylenetetrahydrofolate + reduced_flavodoxin
|
1.5.8.4
dimethylglycine dehydrogenase
|
–
|
M
|
|
MetaCyc:
DIMETHYLGLYCINE-DEHYDROGENASE-RXN
|
|
|
|
[glycine-cleavage_complex_H_protein]_N6-aminomethyldihydrolipoyl-L-lysine + tetrahydrofolate <=> [glycine-cleavage_complex_H_protein]_N6-dihydrolipoyl-L-lysine + 5,10-methylenetetrahydrofolate + NH3
|
2.1.2.10
aminomethyltransferase
|
–
|
M
|
|
MetaCyc:
GCVT-RXN
|
|
|
|
a_[methyl-Co(III)_corrinoid_Fe-S_protein] + tetrahydrofolate <=> [Co(I)_corrinoid_Fe-S_protein] + 5-methyltetrahydrofolate + H+
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
M
|
|
MetaCyc:
METHCOCLTH-RXN
|
|
|
|
10-formyltetrahydrofolate + L-methionyl-[initiator_tRNAMet] <=> tetrahydrofolate + N-formyl-L-methionyl-[initiator_tRNAmet] + H+
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
MetaCyc:
METHIONYL-TRNA-FORMYLTRANSFERASE-RXN
|
|
|
|
N5-hydroxy-L-ornithine + 10-formyltetrahydrofolate <=> N5-formyl-N5-hydroxy-L-ornithine + tetrahydrofolate
|
not assigned
|
–
|
M
|
|
MetaCyc:
RXN-11127
|
|
|
|
CMP + 5,10-methylenetetrahydrofolate + H2O <=> 5-hydroxymethylcytidine_5''-phosphate + tetrahydrofolate
|
2.1.2
|
–
|
M
|
|
MetaCyc:
RXN-15911
|
|
|
|
dTDP-4-amino-4,6-dideoxy-alpha-D-glucopyranose + 10-formyltetrahydrofolate <=> dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + tetrahydrofolate + H+
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-19790
|
|
|
|
[methyl-Co(III)_glycine_betaine-specific_corrinoid_protein] + tetrahydrofolate <=> 5-methyltetrahydrofolate + [Co(I)_glycine_betaine-specific_corrinoid_protein] + H+
|
2.1.1.hi
|
–
|
M
|
|
MetaCyc:
RXN-21058
|
|
|
|
[methyl-Co(III)_proline_betaine-specific_corrinoid_protein] + tetrahydrofolate <=> 5-methyltetrahydrofolate + [Co(I)_proline_betaine-specific_corrinoid_protein] + H+
|
2.1.1.M73
|
–
|
M
|
|
MetaCyc:
RXN-21063
|
|
|
|
5-methyltetrahydrofolate + cob(I)alamin-[methionine_synthase] + H+ <=> tetrahydrofolate + methylcob(III)alamin-[methionine_synthase]
|
not assigned
|
–
|
|
|
MetaCyc:
RXN-21539
|
|
|
|
3-(methylthio)propanoate + tetrahydrofolate <=> 3-Mercaptopropionate + 5-methyltetrahydrofolate
|
2.1.1
|
–
|
M
|
|
MetaCyc:
RXN-9738
|
|
|
|
sarcosine + oxidized_electron_transfer_flavoprotein + tetrahydrofolate + H+ <=> glycine + 5,10-methenyltetrahydrofolate + reduced_flavodoxin
|
1.5.8
|
–
|
M
|
|
MetaCyc:
RXN66-577
|
|
|
|
dATP + formate + tetrahydrofolate <=> dADP + phosphate + 10-formyltetrahydrofolate
|
6.3.4.3
formate---tetrahydrofolate ligase
|
–
|
|
|
BRENDA:
BS699
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP + FADH2 + O2 <=> dTMP + tetrahydrofolate + FAD + H2O2
|
2.1.1.148
thymidylate synthase (FAD)
|
–
|
|
|
BRENDA:
BS398698
|
|
|
|
5,10-methylentetrahydrofolate + uracil1939_in_23S_rRNA + FADH2 <=> tetrahydrofolate + 5-methyluracil1939_in_23S_rRNA + FAD
|
2.1.1.B117
|
–
|
|
|
BRENDA:
BR51552
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP + FADH2 <=> dTMP + tetrahydrofolate + FAD
|
2.1.1.148
thymidylate synthase (FAD)
|
–
|
B
|
|
BRENDA:
BS354165
|
|
|
|
5,10-methylenetetrahydrofolate + uracil54_in_tRNA + FADH2 <=> tetrahydrofolate + 5-methyluracil54_in_tRNA + FAD
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
BRENDA:
BS455098
|
|
|
|
5,10-methylenetetrahydrofolate + tRNA_UpsiC + FADH2 <=> tetrahydrofolate + tRNA_TpsiC + FAD+
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
BRENDA:
BS387558
|
|
|
|
N10-formyltetrahydropteroylglutamate + 5''-phosphoribosyl-5-formamino-4-imidazole_carboxamide_ribonucleotide <=> tetrahydrofolate + 5''-phosphoribosyl-5-formamido-4-imidazole_carboxamide_ribonucleotide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS320061
|
|
|
|
N10-formyltetrahydropteroyltriglutamate + 5''-phosphoribosyl-5-formamino-4-imidazole_carboxamide_ribonucleotide <=> tetrahydrofolate + 5''-phosphoribosyl-5-formamido-4-imidazole_carboxamide_ribonucleotide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS320064
|
|
|
|
N10-formyltetrahydropteroylheptaglutamate + 5''-phosphoribosyl-5-formamino-4-imidazole_carboxamide_ribonucleotide <=> tetrahydrofolate + 5''-phosphoribosyl-5-formamido-4-imidazole_carboxamide_ribonucleotide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS320068
|
|
|
|
N10-formyltetrahydropteroylhexaglutamate + 5''-phosphoribosyl-5-formamino-4-imidazole_carboxamide_ribonucleotide <=> tetrahydrofolate + 5''-phosphoribosyl-5-formamido-4-imidazole_carboxamide_ribonucleotide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS320067
|
|
|
|
N10-formyltetrahydropteroylpentaglutamate + 5''-phosphoribosyl-5-formamino-4-imidazole_carboxamide_ribonucleotide <=> tetrahydrofolate + 5''-phosphoribosyl-5-formamido-4-imidazole_carboxamide_ribonucleotide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS320066
|
|
|
|
N10-formyltetrahydropteroyltetraglutamate + 5''-phosphoribosyl-5-formamino-4-imidazole_carboxamide_ribonucleotide <=> tetrahydrofolate + 5''-phosphoribosyl-5-formamido-4-imidazole_carboxamide_ribonucleotide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS320065
|
|
|
|
S-aminomethyldihydrolipoylprotein + tetrahydrofolate <=> enzyme_N6-(dihydrolipoyl)lysine + 5,10-methylenetetrahydrofolate + NH3
|
2.1.2.10
aminomethyltransferase
|
–
|
|
|
BRENDA:
BR43939
|
|
|
|
tetrahydrofolate + 2-methyl-L-serine <=> 5,10-methylenetetrahydrofolate + D-alanine + H2O
|
2.1.2.7
D-alanine 2-hydroxymethyltransferase
|
–
|
|
|
BRENDA:
BS320080
|
|
|
|
hydroxycobalamin + 5-methyltetrahydrofolate <=> methylcobalamin + tetrahydrofolate
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
|
|
BRENDA:
BS420788
|
|
|
|
2-(dimethylsulfonio)propanoate + tetrahydrofolate <=> 2-(methylsulfanyl)propanoate + 5-methyltetrahydrofolate
|
2.1.1.269
dimethylsulfoniopropionate demethylase
|
–
|
|
|
BRENDA:
BS403406
|
|
|
|
2-(dimethylsulfonio)propanoate + tetrahydrofolate <=> 3-(methylthio)propanoate + 5-methyltetrahydrofolate
|
2.1.1.269
dimethylsulfoniopropionate demethylase
|
–
|
|
|
BRENDA:
BS453913
|
|
|
|
tetrahydrofolate + 2''-deoxyuridine_5''-monophosphate <=> 7,8-dihydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS319738
|
|
|
|
a_[methyl-Co(III)_corrinoid_Fe-S_protein] + tetrahydrofolate <=> [Co(I)_corrinoid_Fe-S_protein] + 5-methyltetrahydrofolate
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
B
|
|
BRENDA:
BR50170
|
|
|
|
[Co(I)_corrinoid_Fe-S_protein] + 5-methyltetrahydrofolate <=> a_[methyl-Co(III)_corrinoid_Fe-S_protein] + tetrahydrofolate
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
|
|
BRENDA:
BS421717
|
|
|
|
7,8-dihydrofolate + reduced_acetylpyridine_adenine_dinucleotide <=> tetrahydrofolate + 3-acetylpyridine_adenine_dinucleotide
|
1.5.1.3
dihydrofolate reductase
|
–
|
|
|
BRENDA:
BS259282
|
|
|
|
CH3-tetrahydrofolate + CO + CoA <=> CH3-CO-S-CoA + tetrahydrofolate
|
2.3.1.169
CO-methylating acetyl-CoA synthase
|
–
|
|
|
BRENDA:
BS359567
|
|
|
|
tetrahydrofolate + deoxyuridine <=> 7,8-dihydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS319737
|
|
|
|
anthranilate + tetrahydrofolate + O2 <=> 3-Hydroxyanthranilate + 7,8-dihydrofolate + H2O2
|
1.14.16.3
anthranilate 3-monooxygenase
|
–
|
|
|
BRENDA:
BS288192
|
|
|
|
2 L-arginine + 3 tetrahydrofolate + 4 O2 <=> 2 L-citrulline + 2 NO + 3 folate + 4 H2O
|
1.14.14.47
nitric-oxide synthase (flavodoxin)
|
–
|
|
|
BRENDA:
BS438667
|
|
|
|
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate <=> N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
|
2.1.2.5
glutamate formimidoyltransferase
|
–
|
|
|
BRENDA:
BS421080
|
|
|
|
(+)-episesamin + tetrahydrofolate <=> 4-[(1S,3aR,4R,6aR)-4-(2H-1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2-diol + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BS442630
|
|
|
|
(-)-asarinin + tetrahydrofolate <=> 4-[(1S,3aS,4R,6aS)-4-(2H-1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2-diol + 4,4''-[(1R,3aS,4S,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]di(benzene-1,2-diol) + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BS442632
|
|
|
|
(+)-sesaminol + tetrahydrofolate <=> 4-[(1S,3aR,4S,6aR)-4-(6-hydroxy-2H-1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2-diol + 5-[(1S,3aR,4S,6aR)-4-(3,4-dihydroxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2,4-triol + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BS443901
|
|
|
|
(+)-sesamolin + tetrahydrofolate <=> 4-[(1S,3aR,4R,6aR)-4-[(2H-1,3-benzodioxol-5-yl)oxy]tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2-diol + 4-[[(1R,3aR,4S,6aR)-4-(2H-1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]oxy]benzene-1,2-diol + 4-[(1S,3aR,4R,6aR)-4-(3,4-dihydroxyphenoxy)tetrahydro-1H,3H-furo[3,4-c]furan-1-yl]benzene-1,2-diol + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BS442631
|
|
|
|
piperine + tetrahydrofolate <=> (2E,4E)-5-(3,4-dihydroxyphenyl)-1-(piperidin-1-yl)penta-2,4-dien-1-one + 5,10-methylenetetrahydrofolate
|
2.1.5.1
sesamin methylene transferase
|
–
|
|
|
BRENDA:
BS443852
|
|
|
|
tetrahydrofolate + hydroxymethylserine <=> 5,10-methylenetetrahydrofolate + D-serine + H2O
|
2.1.2.7
D-alanine 2-hydroxymethyltransferase
|
–
|
|
|
BRENDA:
BS320082
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP <=> tetrahydrofolate + dTMP
|
2.1.1.45
thymidylate synthase
|
–
|
|
|
BRENDA:
BS375949
|
|
|
|
tetrahydrofolate + 2-ethyl-DL-serine <=> 5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O
|
2.1.2.7
D-alanine 2-hydroxymethyltransferase
|
–
|
|
|
BRENDA:
BS451913
|
|
|
|
tetrahydrofolate + (-)-ethylserine <=> 5,10-methylenetetrahydrofolate + D-2-aminobutyrate + H2O
|
2.1.2.7
D-alanine 2-hydroxymethyltransferase
|
–
|
|
|
BRENDA:
BS320081
|
|
|
|
S-adenosyl-L-methionine + tetrahydrofolate <=> 5-methyltetrahydrofolate + S-adenosyl-L-homocysteine
|
2.1.1.13
methionine synthase
|
–
|
|
|
BRENDA:
BS289528
|
|
|
|
dATP + tetrahydrofolate + L-glutamate <=> dADP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS471
|
|
|
|
ITP + tetrahydrofolate + L-glutamate <=> IDP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS472
|
|
|
|
tetrahydropteroyl-(gamma-glutamyl)n + (n-1)_H2O <=> tetrahydrofolate + (n-1)_L-glutamate
|
3.4.19.9
folate gamma-glutamyl hydrolase
|
–
|
|
|
BRENDA:
BR48232
|
|
|
|
CTP + tetrahydrofolate + L-glutamate <=> CDP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS474
|
|
|
|
UTP + tetrahydrofolate + L-glutamate <=> UDP + phosphate + 5,6,7,8-tetrahydropteroyl-Glu2
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS473
|
|
|
|
10-formyltetrahydrofolate + carbocyclic_beta-glycinamide_ribonucleotide <=> tetrahydrofolate + formylglycinamide_ribonucleotide
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
|
|
BRENDA:
BS320046
|
|
|
|
10-formyltetrahydrofolate + 5''-phosphoribosyl-5-formamino-4-imidazole_carboxamide_ribonucleotide <=> tetrahydrofolate + 5''-phosphoribosyl-5-formamido-4-imidazole_carboxamide_ribonucleotide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS320063
|
|
|
|
10-formyltetrahydrofolate + L-methionyl-tRNAfMet <=> tetrahydrofolate + tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BR43947
|
|
|
|
10-formyltetrahydrofolate + phenylalanyl-tRNAfMet + H2O <=> tetrahydrofolate + N-formylphenylalanyl-tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS320087
|
|
|
|
10-formyltetrahydrofolate + valyl-tRNAfMet + H2O <=> tetrahydrofolate + N-formylvalyl-tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS320088
|
|
|
|
10-formyltetrahydrofolate + 5-amino-imidazole-4-thiocarboxamide_ribonucleotide <=> tetrahydrofolate + 6-mercaptopurine_ribonucleotide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS320072
|
|
|
|
10-formyltetrahydrofolate + 5-aminoimidazole-4-carboxamide_ribonucleotide <=> tetrahydrofolate + 5-formamido-4-imidazole_carboxamide_ribonucleotide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS320058
|
|
|
|
10-formyltetrahydrofolate + isoleucyl-tRNAfMet + H2O <=> tetrahydrofolate + N-formylisoleucyl-tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS320089
|
|
|
|
10-formyltetrahydrofolate + methionyl-tRNA1Val(CAU) + H2O <=> tetrahydrofolate + N-formylmethionyl-tRNA1Val(CAU)
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS320091
|
|
|
|
10-formyltetrahydrofolate + methionyl-tRNAmMet + H2O <=> tetrahydrofolate + N-formylmethionyl-tRNAmMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS320090
|
|
|
|
10-formyltetrahydrofolate + Met-tRNA <=> tetrahydrofolate + N-formylmethionyl-tRNAMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS451921
|
|
|
|
10-formyltetrahydrofolate + (alpha,beta)-glycinamide_ribonucleotide <=> tetrahydrofolate + formylglycinamide_ribonucleotide
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
|
|
BRENDA:
BS320039
|
|
|
|
10-formyltetrahydrofolate + O-phosphonate_carbocyclic_glycinamide_ribonucleotide <=> tetrahydrofolate + O-phosphonate-ribosyl-N-formylglycinamide
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
|
|
BRENDA:
BS320055
|
|
|
|
10-formyltetrahydrofolate + E._coli_L-methionyl-tRNAfMet <=> tetrahydrofolate + tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS453919
|
|
|
|
10-formyltetrahydrofolate + E._coli_L-methionyl-tRNAfMet <=> tetrahydrofolate + E._coli_N-formylmethionyl-tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS451916
|
|
|
|
10-formyltetrahydrofolate + E.coli_L-methionyl-tRNAfMet <=> tetrahydrofolate + E.coli_N-formylmethionyl-tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS451915
|
|
|
|
10-formyltetrahydrofolate + E._coli_L-isoleucyl-tRNAfMet <=> tetrahydrofolate + E._coli_N-formylisoleucyl-tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS451917
|
|
|
|
10-formyltetrahydrofolate + E._coli_L-valyl-tRNAfMet <=> tetrahydrofolate + N-formylvalyl-tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS453920
|
|
|
|
10-formyltetrahydrofolate + E._coli_L-valyl-tRNAfMet <=> tetrahydrofolate + E._coli_N-formylvalyl-tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS451918
|
|
|
|
10-formyltetrahydrofolate + bovine_mitochondrial_L-methionyl-tRNA <=> tetrahydrofolate + bovine_mitochondrial_N-formylmethionyl-tRNA
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS451919
|
|
|
|
10-formyltetrahydrofolate + E._coli_L-methionyl-tRNAmMet <=> tetrahydrofolate + N-formylmethionyl-tRNAmMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS453922
|
|
|
|
10-formyltetrahydrofolate + E._coli_L-methionyl-tRNAmMet <=> tetrahydrofolate + E._coli_N-formylmethionyl-tRNAmMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS451920
|
|
|
|
10-formyltetrahydrofolate + E._coli_L-methionyl-tRNA1Val(CAU) <=> tetrahydrofolate + E._coli_N-formylisoleucyl-tRNA1Val(CAU)
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS451922
|
|
|
|
10-formyltetrahydrofolate + L-isoleucyl-tRNAfMet <=> tetrahydrofolate + N-formylisoleucyl-tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS453921
|
|
|
|
10-formyltetrahydrofolate + L-phenylalanyl-tRNAfMet + H2O <=> tetrahydrofolate + N-formylphenylalanyl-tRNAfMet
|
2.1.2.9
methionyl-tRNA formyltransferase
|
–
|
|
|
BRENDA:
BS375569
|
|
|
|
10-formyltetrahydrofolate + N5-hydroxy-L-ornithine <=> tetrahydrofolate + N2-formyl-N5-hydroxyornithine
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
|
|
BRENDA:
BS320054
|
|
|
|
10-formyltetrahydrofolate + N5-hydroxy-L-ornithine <=> tetrahydrofolate + N5-formyl-N5-hydroxyornithine
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
|
|
BRENDA:
BS378853
|
|
|
|
N10-formyltetrahydropteroylglutamate + 5-aminoimidazole-4-carboxamide_ribonucleotide <=> tetrahydrofolate + 5-formamido-4-imidazole_carboxamide_ribonucleotide
|
2.1.2.3
phosphoribosylaminoimidazolecarboxamide formyltransferase
|
–
|
|
|
BRENDA:
BS320057
|
|
|
|
5,10-methylenetetrahydrofolate + dUMP + FMNH2 <=> dTMP + tetrahydrofolate + FMN
|
2.1.1.148
thymidylate synthase (FAD)
|
–
|
|
|
BRENDA:
BS354166
|
|
|
|
5-methyltetrahydrofolate + 2-mercaptoethanol <=> S-Methyl-2-mercaptoethanol + tetrahydrofolate
|
2.1.1.13
methionine synthase
|
–
|
|
|
BRENDA:
BS289525
|
|
|
|
syringic_acid + 2 tetrahydrofolate <=> 3,4-dihydroxybenzoate + 2 5-methyltetrahydrofolate
|
2.1.1.341
vanillate/3-O-methylgallate O-demethylase
|
–
|
|
|
BRENDA:
BS439920
|
|
|
|
folate + NADPH + H+ <=> 7,8-dihydrofolate + tetrahydrofolate + NADP+
|
1.5.1.33
pteridine reductase
|
–
|
|
|
BRENDA:
BS394857
|
|
|
|
5,10-methylenetetrahydrofolate + uracil54_in_tRNA + NADPH + H+ <=> tetrahydrofolate + 5-methyluracil54_in_tRNA + NADP+
|
2.1.1.74
methylenetetrahydrofolate---tRNA-(uracil54-C5)-methyltransferase [NAD(P)H-oxidizing]
|
–
|
|
|
BRENDA:
BR43916
|
|
|
|
7,8-dihydrofolate + NADP+ + H+ <=> tetrahydrofolate + NADP+
|
1.5.1.3
dihydrofolate reductase
|
–
|
|
|
BRENDA:
BS408226
|
|
|
|
Cobalamin + 5-methyltetrahydrofolate <=> methylcobalamin + tetrahydrofolate
|
2.1.1.258
5-methyltetrahydrofolate---corrinoid/iron-sulfur protein Co-methyltransferase
|
–
|
|
|
BRENDA:
BS428493
|
|
|
|
ATP + 5,6,7,8-Tetrahydropteroate + L-glutamate <=> ADP + phosphate + tetrahydrofolate
|
6.3.2.17
tetrahydrofolate synthase
|
–
|
|
|
BRENDA:
BS469
|
|
|
|
5,10-methenyltetrahydrofolate + 2-amino-N-ribosylacetamide_5''-phosphate + H2O <=> formylglycinamide_ribonucleotide + tetrahydrofolate + 2-formamido-N-ribosylacetamide_5''-phosphate
|
2.1.2.2
phosphoribosylglycinamide formyltransferase
|
–
|
|
|
BRENDA:
BS320043
|
|
|
|
5-methyltetrahydropteroylmonoglutamate + L-homocysteine <=> tetrahydrofolate + L-methionine
|
2.1.1.14
5-methyltetrahydropteroyltriglutamate---homocysteine S-methyltransferase
|
–
|
|
|
BRENDA:
BS289580
|
|
|
|
5,10-methylenetetrahydrofolate + H2O + CMP <=> tetrahydrofolate + 5-hydroxymethylcytidylate
|
2.1.2.B2
|
–
|
|
|
BRENDA:
BR51681
|
|
|
|
5,10-methylenetetrahydrofolate + H2O + CMP <=> tetrahydrofolate + 5-hydroxymethyl-CMP
|
2.1.2.B2
|
–
|
|
|
BRENDA:
BS454201
|
|
|
|
5,10-methylenetetrahydrofolate + H2O + 2-oxobutyrate <=> 4-Hydroxy-3-methyl-2-oxobutanoic_acid + tetrahydrofolate
|
2.1.2.11
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
–
|
|
|
SABIO-RK:
14653
|
|
|
|
3-methyl-2-oxopentanoate + H2O + 5,10-methylenetetrahydrofolate <=> 3-(Hydroxymethyl)-3-methyl-2-oxopentanoic_acid + tetrahydrofolate
|
2.1.2.11
3-methyl-2-oxobutanoate hydroxymethyltransferase
|
–
|
|
|
SABIO-RK:
14655
|
|